Why is preservative free and phosphate free important?

"The ideal artificial lubricant should be preservative free; contain potassium, bicarbonate, and other electrolytes; and have a polymeric system to increase its retention time."*

Why is preservative free important?

Preservatives can:

  • Damage the cells of the ocular surface.
  • Destroy the natural tear film.
  • Be the cause of intolerance reactions.

Modern tear substitute preparations are entirely free of preservatives.

Why is phosphate free important?

Phosphates in buffers can exert detrimental influence:

  • Practically insoluble crystals can form with calcium, which is released from damaged cells and can result in persistent impairment of vision. The extent of corneal epithelial damage is a decisive factor for calcification.

Eye drops that are used for treatment of dry eyes, particularly after ophthalmic surgery or injuries with epithelial damage, should not contain phosphate buffers.

Less is more:

CandorVision – Your eyes are everything!

References: *MedScape reference 2012, C Stephen Foster, MD, FACS, FACR, FAAO† Clinical Professor of Ophthalmology, Harvard Medical School; Consulting Staff, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary; Founder and President, Ocular Immunology and Uveitis Foundation, Massachusetts Eye Research and Surgery Institution;

Bischoff G, Teping C Klin. Monatsbl. Augenheilkunde 2010: no2 vol 227; Schrage NF, Frentz M, Reim M Br J Ophthalmol 2010 Br J Ophthalmol 2010; 94, 11: 1519; Frentz M et al. ATLA 2008, 36, 25-32; Schrage NF EVEIT; EMA Press Release of 13.12.2012: Questions and answers on the use of phosphates in eye drops. Doc Ref.: EMAOMP/753373/2012; data on file

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