OCUNOX™

When your patients experience symptoms of dry eye, or after eye surgery or an eye injury you may recommend using eye drops (artificial tears) or an eye ointment.


Why recommended OCUNOX™?

OCUNOX™ eye ointment:

  • Improves the tear film and protects the surface of the eye.
  • Is preservative and phosphate free and is usually well tolerated.
  • Enables optimal moisturisation overnight.

How does OCUNOX™ work?

OCUNOX™ improves the tear film and protects the surface of the eye. Due to its particularly smooth texture, OCUNOX™ gently moisturizes your eyes, stabilizes the tear film and prevents tears from evaporating while you sleep. OCUNOX™ contains Vitamin A, a natural component of the tear film, that supports tolerance and helps ensure that the ointment mixes well with available tears to relieve the burning sensation of dry or tired eyes.

OCUNOX™ helps the eyelids slide easily over the surface of the cornea and conjunctiva, keeping the eyelids smooth and preventing crusting around the eye.



OCUNOX™:

  • Contains 250 I.U./g retinol palmitate (vitamin A), paraffin, liquid paraffin, wool fat and white petrolatum.
  • Improves the tear film and protects the surface of the eye.

Retinol:

Retinol

Retinol palmitate is the ester of retinol (vitamin A) and palmitic acid. Vitamin A is absorbed from food as retinylesters or β–carotine.

Retinol is important for:

  • Growth & differentiation of epithelial & mesenchymal cell structures.
  • Prevention of keratinisation of mucous membranes.

Also:

  • Specific Retinol receptors were detected in the cytosol of corneal epithelium, stroma & endothel.
  • Retinol is absorbed by the corneal epithelium, stroma and endothelium.
  • Lack of Vitamin A causes morphologic changes to the anterior segment of the eye.

Who can use OCUNOX™?

Children, pregnant and breast-feeding women can safely use OCUNOX™.

If your patients use OCUNOX™ during the day, their vision will be impaired for some time because of the fatty consistency of the ointment. For the duration of this impairment of vision they should not drive a car, use machines or perform any work without stable footing.

OCUNOX™ must not be used while wearing contact lenses.


How often and how long can OCUNOX™ be used?

The frequency of use depends on your patients’ individual discomfort and habits. OCUNOX™ can be used in addition to lubricating eye drops. Ideally combine with our preservative-free, phosphate-free, 300-drop HYLO™ / HYLO™Gel.

Usually your patients should apply OCUNOX™ once a day before bedtime. The duration of treatment is not limited.


How should OCUNOX™ be applied?

Only use OCUNOX™ if the sealing ring of the tube is intact. Eye ointments should be used by avoiding any contact between the tube-tip and the eye or the skin.

Unscrew the cap covering the nozzle. Tilt back your head a little, then slightly retract the lower eyelid from the eye. Apply a slight pressure to the tube to squeeze a small amount of ointment into the conjunctival sac. Slowly close the eye.

Close the tube carefully after use. Do not fold or coil up the tube. A tube of OCUNOX™ should not be shared. Store at room temperature (15 to 25 °C).


When should OCUNOX™ not be used?

OCUNOX™ should not be used if you are sensitive to any of the ingredients. OCUNOX™ is preservative and phosphate free and is usually well tolerated.

OCUNOX™ must not be used while wearing contact lenses.


Why is preservative-free and phosphate free important?

Preservatives can damage the cells of the eye surface, destroy the natural tear film and cause intolerance.

Phosphates can form practically insoluble crystals due to the reaction with calcium (which is released from damaged cells of the eye surface) and can result in impairment of vision. The extent of corneal epithelial damage is a decisive factor for calcification. Modern eye drops and ointments used for treatment of dry eyes, particularly after ophthalmic surgery or injuries with epithelial damage, should not contain phosphates.

Because they last long on the surface of the eye, it is particularly important that ointment-like eye preparations do not contain any harmful substances.

» Read more about why preservation free products are important

For more information please read the package insert! As with all health concerns you should consult your doctor when your symptoms persist.

OCUNOX™ eye ointment is entirely free of preservatives and phosphates. Nonetheless, due to its unique formulation, OCUNOX™ eye ointment can be used for up to 6 months after first opening.

References: Wolf G. Physiol Rev 64, 3 (1984) 873; Wiggert B. et al. Biochem Biophys Acta 491 (1977) 104; Lee V.H.L. Int J Pharm 11 (1982) 21; Sommer A., Emran N. Am J Opthalmol 93 (1982) 84 Heinsius E. Klin Mbl Augenheilkd 98 (1937) 246; Beitch I. Invest Opthalmol 9, 11 (1977) 827 ; Ohashi et al Am J Opthalmol 105 (1988) 523; Tseng S.C.G. Trans Opthalmol Soc UK 104 (1985) 489; Marquardt R. Therapie des trochenen Auges “Das Trochene Auge in Klinik und Praxis” (1991) Springer; Kim et al. Am J Opthal 147 (2009) Bischoff G, Teping C Klin. Monatsbl. Augenheilkunde 2010: no2 vol 227; Schrage NF, Frentz M, Reim M Br J Ophthalmol 2010 Br J Ophthalmol 2010; 94, 11: 1519; data on file

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