Why is HYLO® Bottle So Unique?

Instilling eye drops properly may require a good amount of practice as many individuals struggle to precisely dispense one drop or have a poor aim. [1] With HYLO® lubricating eye drops, that is no longer a concern.

Modern eye drops are available in single-dose or multi-dose containers. But, single-dose units have several inconveniences, including a small volume and in-use sterility, and difficulties in opening and squeezing the vials. This is inconvenient and costly for many users who require multiple doses throughout the day and elderly patients who may lack dexterity. [2, 3] Those patients who frequently use eye drops may opt to using multi-dose containers; however, the squeeze mechanism to dispense the drops requires dexterity and high force to avoid unwanted multiple doses at once. [4]

Not only that, but the squeeze bottles also filter the air back into the solution, which exposes the eye drop solutions to potential risks of contamination. [5] As modern eye drops tend to avoid the use of preservatives, knowing their negative effects [6], squeeze bottles with no preservatives only have a greater chance of being contaminated. Using contaminated eye drops may increase the risks of ocular infections and eye injuries. [7-9]

All the described downsides of single-use and multi-dose containers can be prevented with the right technology. HYLO® bottle is a multi-dose, easy-to-use, airless bottle for lubricating eye drops proven in millions of patients!

German-engineered, airless, multi-dose system

HYLO® bottle is designed with top German technology. The bottle system ensures an airtight environment of the internal sachet containing the eye drops. As the content is protected from contamination via air, HYLO® bottle enables preservative-free storage of eye drops, sterile for 6 months after first use, longer than other modern eye drop containers.

The innovative HYLO® bottle system only requires simple pump movements to dispense the liquid. Using the thumb, index finger, and middle finger, one drop is dispensed at a time. This ensures that the eye is not overflown with eye drops and that each drop is accurately dispensed while facilitating easy application of the eye drops for those who may lack dexterity. This precise dispensing mechanism of HYLO bottle guarantees 300 drops for regular HYLO® and 150 drops for our new HYLO® mini.

Here at CandorVision™, all members of the HYLO® lubricating eye drop family comes in the HYLO® bottle for preservative-free, convenient, and precise user experience that every dry eye patient seeks for.

HYLO® family of lubricating eye drops are available for healthcare professionals and patients across Canada. Try now and feel the difference!

CandorVision™ – your eyes are everything!

References

1. Winfield, A J et al. “A study of the causes of non-compliance by patients prescribed eyedrops.” The British journal of ophthalmology vol. 74,8 (1990): 477-80. doi:10.1136/bjo.74.8.477

2. Furrer P, Mayer JM, Gurny R. Ocular tolerance of preservatives and alternatives. Eur J Pharm Biopharm. 2002 May;53(3):263-80. doi: 10.1016/s0939-6411(01)00246-6. PMID: 11976014.

3. Dietlein TS, Jordan JF, Lüke C, Schild A, Dinslage S, Krieglstein GK. Self-application of single-use eyedrop containers in an elderly population: comparisons with standard eyedrop bottle and with younger patients. Acta Ophthalmol. 2008 Dec;86(8):856-9. doi: 10.1111/j.1755-3768.2007.01155.x. Epub 2008 May 20. PMID: 18494743.

4. Connor, A J, and P S Severn. “Force requirements in topical medicine use--the squeezability factor.” Eye (London, England) vol. 25,4 (2011): 466-9. doi:10.1038/eye.2011.5

5. Daehn T, Schneider A, Knobloch J, Hellwinkel OJC, Spitzer MS, Kromer R. Contamination of multi dose eyedrops in the intra and perioperative context. Sci Rep. 2021 Oct 13;11(1):20364. doi: 10.1038/s41598-021-99892-8. PMID: 34645913; PMCID: PMC8514486.

6. Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010 Jul;29(4):312-34. doi: 10.1016/j.preteyeres.2010.03.001. Epub 2010 Mar 17. PMID: 20302969.

7. Schein OD, Wasson PJ, Boruchoff SA, Kenyon KR. Microbial keratitis associated with contaminated ocular medications. Am J Ophthalmol. 1988 Apr 15;105(4):361-5. doi: 10.1016/0002-9394(88)90298-x. PMID: 3358428.

8. Pisella P.J., Pouliquen P., Baudouin C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br. J. Ophthalmol. 2002;86:418–423. doi: 10.1136/bjo.86.4.418.

9. Mayo M.S., Schlitzer R.L., Ward M.A., Wilson L.A., Ahearn D.G. Association of Pseudomonas and Serratia corneal ulcers with use of contaminated solutions. J. Clin. Microbiol. 1987;25:1398–1400. doi: 10.1128/jcm.25.8.1398-1400.1987.